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For patients with type 2 diabetes, the most critical consideration is ensuring continuity of glycemic control

Benchmarking against SUSTAIN-6 and SURPASS-CVOT In the emulation of SUSTAIN-6 comparing semaglutide to sitagliptin, a proxy for placebo, in patients at moderate and high cardiovascular risk (Table 2 and Supplementary Table 19), the hazard ratio (HR) for the primary endpoint was 0.68 (95% confidence interval (CI) 0.600.77) compared to the trial estimate of HR 0.74 (95% CI 0.58 to 0.95)

The ecosystem was already being built

Diet and exercise enhance results and help support long-term, sustainable weight loss

So let us look at how the formula works at any number of units

Be aware that dose changes, including increases, are the most common trigger for this side effect